Sarcopenia and clinical presentation
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Dosyalar
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Sarcopenia is characterized by the progressive generalized loss of muscle function, quality, strength and mass. Although it is
known as a primary geriatric disease, it may also develop in younger individuals secondary to immobilization, malnutrion and
cachexia.
The exact etiology is unknown, but the most commonly suggested contributory factors are a decrease in protein synthesis,
mitochondrial dysfunction, reactive oxygen products, chronic inflammation, nutritional deficiency, loss of perfusion, age-related
neuromuscular alterations, decrease in sex hormone, growth hormone (GH), insulin-like growth factor (IGF-1) and vitamin D levels
together with physical inactivity.
There are severe negative effects on quality of life and the individual’s socio-economic status and thus, sarcopenia is a significant
public health problem. Sarcopenia is strongly correlated with the increased fragility that develops in the elderly and is a significant
risk factor and also an indicator of disability and mortality.
The evaluation of muscle strength and physical performance is mandatory for the diagnosis of sarcopenia. Despite the lack of a
definitive treatment method, the most commonly accepted approaches include physical activity, nutritional supplementation
therapy, and hormonal and new pharmacological agents.
In this review sarcopenia, which is a common but sometimes misdiagnosed condition in clinical practice, is discussed in the light of
current knowledge.
Açıklama
Anahtar Kelimeler
Kaynak
Annals of Medical Research
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Dogru Gunduz, H., Yildirim, T., & Ersoy, Y. (2021). Sarcopenia and clinical presentation . Annals of Medical Research
