Sarcopenia and clinical presentation
| dc.contributor.author | Dogru Gunduz, Hacer | |
| dc.contributor.author | Yildirim, Tulay | |
| dc.contributor.author | Ersoy, Yüksel | |
| dc.date.accessioned | 2022-02-16T12:42:42Z | |
| dc.date.available | 2022-02-16T12:42:42Z | |
| dc.date.issued | 2017 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Sarcopenia is characterized by the progressive generalized loss of muscle function, quality, strength and mass. Although it is known as a primary geriatric disease, it may also develop in younger individuals secondary to immobilization, malnutrion and cachexia. The exact etiology is unknown, but the most commonly suggested contributory factors are a decrease in protein synthesis, mitochondrial dysfunction, reactive oxygen products, chronic inflammation, nutritional deficiency, loss of perfusion, age-related neuromuscular alterations, decrease in sex hormone, growth hormone (GH), insulin-like growth factor (IGF-1) and vitamin D levels together with physical inactivity. There are severe negative effects on quality of life and the individual’s socio-economic status and thus, sarcopenia is a significant public health problem. Sarcopenia is strongly correlated with the increased fragility that develops in the elderly and is a significant risk factor and also an indicator of disability and mortality. The evaluation of muscle strength and physical performance is mandatory for the diagnosis of sarcopenia. Despite the lack of a definitive treatment method, the most commonly accepted approaches include physical activity, nutritional supplementation therapy, and hormonal and new pharmacological agents. In this review sarcopenia, which is a common but sometimes misdiagnosed condition in clinical practice, is discussed in the light of current knowledge. | en_US |
| dc.identifier.citation | Dogru Gunduz, H., Yildirim, T., & Ersoy, Y. (2021). Sarcopenia and clinical presentation . Annals of Medical Research | en_US |
| dc.identifier.doi | 10.5455/jtomc.2016.02.030 | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/47297 | |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Annals of Medical Research | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Sarcopenia and clinical presentation | en_US |
| dc.type | Article | en_US |
