Evaluation of in vitro and in vivo toxic effects of newly synthesized benzimidazole-based organophosphorus compounds

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dc.authoridKUCUKBAY, HASAN/0000-0002-7180-9486
dc.authoridBirhanlı, Ayşe/0000-0003-0870-1226
dc.authoridGüngördü, Abbas/0000-0001-7770-0660
dc.authoridOzmen, Murat/0000-0003-4378-0839
dc.authorwosidKUCUKBAY, HASAN/A-5050-2019
dc.authorwosidBirhanlı, Ayşe/ABH-3226-2020
dc.authorwosidOZMEN, MURAT/A-4874-2009
dc.authorwosidGüngördü, Abbas/A-3009-2015
dc.contributor.authorGungordu, Abbas
dc.contributor.authorSireci, Nihat
dc.contributor.authorKucukbay, Hasan
dc.contributor.authorBirhanli, Ayse
dc.contributor.authorOzmen, Murat
dc.date.accessioned2024-08-04T20:36:13Z
dc.date.available2024-08-04T20:36:13Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis paper reports the toxic properties of eight newly synthesized benzimidazole-based organophosphorus (OP) compounds in Xeno pus laevis in both in vivo and in vitro conditions. For both experiments, a commercial solution of azinphos methyl (AzM, Gusathion M WP25) was used as a reference compound. The 24-h median lethal concentrations (LC50) of all tested compounds were determined for 46th stage tadpoles in the range of 9.54-140.0 mu M. For evaluation of the lethality of the compounds, the activity of the enzyme biomarkers acetylcholinesterase (AChE), carboxylesterase, glutathione S-transferase (GST), glutathione peroxidase, glutathione reductase, lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase were determined in vivo in X. laevis tadpoles exposed to three concentrations (LC50, LC50/2, and LC50/4) of tested compounds. All exposure concentrations of AzM and seven of eight tested compounds caused CaE inhibition in in vivo conditions. Furthermore, the AChE inhibition capacity of tested compounds in commercial electric eel AChE and in X. laevis homogenates and also CaE inhibition capacity in only X. laevis homogenates were assayed for a 30-min in vitro exposure period. Eight OP compounds did not inhibit AChE activity more than 23 percent, but AzM exposure inhibited AChE activity by 26 percent for X. laevis homogenates and 97 percent for electric fish AChE in in vitro conditions. Also. CaE inhibition levels in X. laevis tadpole homogenates were 46 percent for AzM and between 8 percent and 33 percent for other compounds in in vitro conditions. (C) 2012 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipInonu University Research Fund [I.U.A.F. 2008-57]en_US
dc.description.sponsorshipThis study is a part of a comprehensive project that is supported by the Inonu University Research Fund (Project No: I.U.A.F. 2008-57). The authors wish to thank the supporting institution for their financial support of the project.en_US
dc.identifier.doi10.1016/j.ecoenv.2012.10.007
dc.identifier.endpage32en_US
dc.identifier.issn0147-6513
dc.identifier.issn1090-2414
dc.identifier.pmid23116621en_US
dc.identifier.scopus2-s2.0-84869888674en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.1016/j.ecoenv.2012.10.007
dc.identifier.urihttps://hdl.handle.net/11616/95864
dc.identifier.volume87en_US
dc.identifier.wosWOS:000312043100004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofEcotoxicology and Environmental Safetyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOrganophosphorus compoundsen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectElectric eelen_US
dc.subjectXenopus laevisen_US
dc.subjectBiomarkeren_US
dc.titleEvaluation of in vitro and in vivo toxic effects of newly synthesized benzimidazole-based organophosphorus compoundsen_US
dc.typeArticleen_US

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