Diagnostic Scoring in Biliary Atresia

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dc.contributor.authorGungor, Sukru
dc.contributor.authorVarol, Fatma Ilknur
dc.contributor.authorAltundas, Ebubekir
dc.contributor.authorGok, Emre
dc.contributor.authorYildiz, Turan
dc.contributor.authorDemiroz, Sevgi
dc.date.accessioned2026-04-04T13:30:44Z
dc.date.available2026-04-04T13:30:44Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground/Aims: The aim of this study was to develop a diagnostic scoring model to predict the need for intraoperative cholangiography in patients with neonatal cholestasis suspected of having biliary atresia (BA) and to aid in the early diagnosis of BA. Materials and Methods: Data from 70 patients with neonatal cholestasis who underwent intraoperative cholangiography with a preliminary diagnosis of BA between 2019 and 2024 were retrospectively reviewed. Data from patients with and without BA were compared. Thescoring was based on 3 parameters: acholic stool observed clinically on inspection, findings suggestive of BA on ultrasound, and elevated gamma-glutamyl transferase (GGT) levels. The best GGT cut-off point for the diagnosis of BA was determined by receiver operating characteristic analysis. The diagnostic success of the scoring model for BA was statistically evaluated. Results: There were no significant differences in age and gender between BA and non-BA groups. Gamma-glutamyl transferase levels were elevated in all patients. Acholic stools were present in 98% of BA patients. Ultrasound findings suggestive of BA were present in 88.5% of patients with BA. The authors found the best GGT cut-off value for the diagnosis of BA to be >= 366 (73% sensitivity, 77.8% specificity). In the scoring model the authors developed, the presence of 2 parameters provided diagnostic success with high sensitivity (98%) and specificity (83.3%). Conclusion: The study provides a reliable and sensitive diagnostic criterion to determine the need for intraoperative cholangiography in infants with neonatal cholestasis. These data should be validated in larger prospective case series.
dc.identifier.doi10.5152/tjg.2025.24469
dc.identifier.issn2148-5607
dc.identifier.issue11
dc.identifier.orcid0000-0001-5317-7537
dc.identifier.orcid0000-0002-9836-6814
dc.identifier.pmid40418198
dc.identifier.scopus2-s2.0-105006856893
dc.identifier.scopusqualityQ3
dc.identifier.trdizinid1361983
dc.identifier.urihttps://doi.org/10.5152/tjg.2025.24469
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1361983
dc.identifier.urihttps://hdl.handle.net/11616/108352
dc.identifier.volume36
dc.identifier.wosWOS:001629931900006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAves
dc.relation.ispartofTurkish Journal of Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectBiliary atresia
dc.subjectchildren
dc.subjectdiagnosis
dc.subjectscore
dc.titleDiagnostic Scoring in Biliary Atresia
dc.typeArticle

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