Synthesis, Characterization, and Carbonic Anhydrase Inhibitory Properties of Silver(I) Complexes of Benzimidazole Derivatives
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Tarih
2019
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Abstract: The antimicrobial properties of silver compounds and biological properties ofbenzimidazole derivatives have been well known for many years. In the present study, in terms oftheir biological potential, six novel silver(I)-N-alkylbenzimidazole derivatives were synthesized inorder to examine their carbonic anhydrase (CA) inhibitory properties. All complexes werecharacterized by the combination of 1H NMR, 13C NMR, mass, FT-IR spectroscopic methods andelemental analyses. The inhibitory properties of all complexes were tested on the esterase activityof human CA I and II (hCA I and hCA II). Acetazolamide was used as a standard. All complexesinhibited the hCA I and hCA II activity in the range of 27.37-29.58 µM and 20.93-27.25 µM,respectively.
Açıklama
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Kaynak
Journal of the Turkish Chemical Society, Section A: Chemistry
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
6
Sayı
2
Künye
KARATAŞ M. O,ERGÜN A (2019). Synthesis, Characterization, and Carbonic Anhydrase Inhibitory
Properties of Silver(I) Complexes of Benzimidazole Derivatives. Journal of the Turkish Chemical Society, Section A: Chemistry, 6(2), 253 - 260. Doi: 10.18596/jotcsa.546960
