Lack of association between catechol-Omethyltransferase and schizophrenia in a Turkish population
Küçük Resim Yok
Dosyalar
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Biochemistry Society
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Catechol-O-methyltransferase (COMT) is the key molecule in the catabolism of catecholamines like dopamine which is an important molecule in schizophrenia. Due to its function and location COMT gene is a strong candidate gene for schizophrenia. The aim of this study was to investigate the possible associations of 3 COMT single nucleotide polymorphisms (SNPs) and schizophrenia in our population. COMT enzyme activity is regulated by a widely known Val158Met polymorphism (rs4680), along with the variation of the SNPs rs737865 and rs165599. Methods: Val158Met polymorphism (rs4680), the SNPs rs737865 and rs165599 were the targets of this study. The study was performed with 96 patients (66 male and 30 female) and 100 controls (47 male and 53 female) from Malatya region on eastern part of Turkey by using TaqMan genotyping assays. Results: We couldn’t find a significant difference between the schizophrenia patients and normal controls for any of the SNPs that were studied. The genotype frequencies in both the patient and control groups satisfied the Hardy– Weinberg equilibrium. No significant gender differences were observed for the SNPs that were investigated. No significant difference was observed in the allele or genotype frequencies as well. Conclusion: COMT gene doesn’t appear to be a risk factor in this population of schizophrenia patients in Turkey. © 2015, Turkish Biochemistry Society. All rights reserved.
Açıklama
Turkish Journal of Biochemistry
Volume 40, Issue 3, 1 June 2015, Pages 205-209
Anahtar Kelimeler
catechol methyltransferase, genomic DNA
Kaynak
Türk Biyokimya Dergisi
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
40
Sayı
3
Künye
Acar, C., Sözen, M.M., Gözükara, H., Orman, K., Kartalcı, Ş. Lack of association between catechol-Omethyltransferase and schizophrenia in a Turkish population. (2015). Turkish Journal of Biochemistry.
