Risk factors of disease severity and mechanical ventilation requirement in childhood Guillain-Barre Syndrome
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish J Pediatrics
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background. This study aimed to investigate the risk factors associated with the severity of the disease, the need for mechanical ventilation (MV) and poor prognosis in the early stages of Guillain-Barre Syndrome (GBS). Methods. Data of children who met GBS diagnostic criteria were evaluated retrospectively. The sample was divided into three binary subgroups according to severe GBS (Hughes Functional Grading Scale [HFGS] >= 4 at admission), mechanical ventilation (MV) requirement, and poor prognosis (inability to walk independently, HFGS >= 3 after six months). Various clinical, laboratory and electrophysiological parameters were compared between these subgroups. Results. The mean age of 63 children with GBS was 91.55 +/- 49.09 months. 13 (20.6%) patients required MV and 4 (6.3%) patients died. Associated risk factors for the need for MV in severe GBS were found to be autonomic dysfunction, bulbar palsy, sensory impairment, lowest total Medical Research Council (MRC) scale for muscle strength score at admission, high modified Erasmus GBS respiratory failure score (mEGRIS), high neutrophillymphocyte ratios (NLR) and high systemic immune-inflammation index (SII) values (p<0.001, p =0.003, p =0.033, p <0.001, p <0.001, p =0.037 and p =0.042, respectively). The lowest total MRC scale for muscle strength score at admission was a significant indicator of poor prognosis (p<0.001). Conclusions. Autonomic dysfunction, bulbar palsy, sensory impairment, lowest total MRC scale for muscle strength score at admission, high mEGRIS score, high NLR and SII values are potential risk factors for the need for MV in children with severe GBS. The lowest total MRC scale for muscle strength score at admission was associated with poor prognosis.
Açıklama
Anahtar Kelimeler
Guillain-Barr & eacute, Syndrome, disease severity, mechanical ventilation, prognosis, risk factors, pediatric
Kaynak
Turkish Journal of Pediatrics
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
66
Sayı
6
