Risk factors of disease severity and mechanical ventilation requirement in childhood Guillain-Barre Syndrome

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dc.contributor.authorYucel, Gul
dc.contributor.authorArslan, Ahmet Kadir
dc.contributor.authorOzgor, Bilge
dc.contributor.authorGungor, Serdal
dc.date.accessioned2026-04-04T13:31:23Z
dc.date.available2026-04-04T13:31:23Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground. This study aimed to investigate the risk factors associated with the severity of the disease, the need for mechanical ventilation (MV) and poor prognosis in the early stages of Guillain-Barre Syndrome (GBS). Methods. Data of children who met GBS diagnostic criteria were evaluated retrospectively. The sample was divided into three binary subgroups according to severe GBS (Hughes Functional Grading Scale [HFGS] >= 4 at admission), mechanical ventilation (MV) requirement, and poor prognosis (inability to walk independently, HFGS >= 3 after six months). Various clinical, laboratory and electrophysiological parameters were compared between these subgroups. Results. The mean age of 63 children with GBS was 91.55 +/- 49.09 months. 13 (20.6%) patients required MV and 4 (6.3%) patients died. Associated risk factors for the need for MV in severe GBS were found to be autonomic dysfunction, bulbar palsy, sensory impairment, lowest total Medical Research Council (MRC) scale for muscle strength score at admission, high modified Erasmus GBS respiratory failure score (mEGRIS), high neutrophillymphocyte ratios (NLR) and high systemic immune-inflammation index (SII) values (p<0.001, p =0.003, p =0.033, p <0.001, p <0.001, p =0.037 and p =0.042, respectively). The lowest total MRC scale for muscle strength score at admission was a significant indicator of poor prognosis (p<0.001). Conclusions. Autonomic dysfunction, bulbar palsy, sensory impairment, lowest total MRC scale for muscle strength score at admission, high mEGRIS score, high NLR and SII values are potential risk factors for the need for MV in children with severe GBS. The lowest total MRC scale for muscle strength score at admission was associated with poor prognosis.
dc.identifier.doi10.24953/turkjpediatr.2024.4658
dc.identifier.endpage757
dc.identifier.issn0041-4301
dc.identifier.issue6
dc.identifier.orcid0000-0003-3875-6770
dc.identifier.orcid0000-0001-8626-9542
dc.identifier.pmid39807741
dc.identifier.scopus2-s2.0-85215596050
dc.identifier.scopusqualityQ3
dc.identifier.startpage746
dc.identifier.trdizinid1289381
dc.identifier.urihttps://doi.org/10.24953/turkjpediatr.2024.4658
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1289381
dc.identifier.urihttps://hdl.handle.net/11616/108772
dc.identifier.volume66
dc.identifier.wosWOS:001386755800009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish J Pediatrics
dc.relation.ispartofTurkish Journal of Pediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectGuillain-Barr & eacute
dc.subjectSyndrome
dc.subjectdisease severity
dc.subjectmechanical ventilation
dc.subjectprognosis
dc.subjectrisk factors
dc.subjectpediatric
dc.titleRisk factors of disease severity and mechanical ventilation requirement in childhood Guillain-Barre Syndrome
dc.typeArticle

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