Severe extrapyramidal symptoms due to sulpiride and fluoxetine combination in a case of OCD
Küçük Resim Yok
Tarih
2001
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Sulpiride is an antipsychotic agent which has an antidepressant effect in low doses. The combination of antipsychotics in lower dosages with antidepressants in obsessive-compulsive disorder (OCD) patients has also been reported to be useful. The case reported was a 53 years old female patient with OCD and major depression according to the DSM-IV diagnostic criteria. OCD diagnosis was present for six years and she had been depressied for the last six months. She was accepted as having resistant OCD according to the patient's history. After she was hospitalized, the treatment began with fluoksetin 20 mg/day. In the second week fluoksetin dosage was raised to 40 mg/day and 200 mg/day sulpiride was added. On the third day of combination treatment, severe extrapyramidal symptoms emerged and this prompted us to quit the use of sulpiride. Biperiden 3 mg/day was ordered in order to relieve those side effects. As these precautions were not efficacious, fluoksetin dosage was lowered to 20 mg/day, and then it was quitted. Diphenhidramine 100 mg/day, propranolol 40 mg/day and diazepam 10 mg/day were ordered. Except chewing movements extrapyramidal symptoms lasted for a week.
Açıklama
Anahtar Kelimeler
Drug interaction, Extrapyramidal symptoms, Fluoksetine, Obsessive-compulsive disorders, Sulpiride
Kaynak
Klinik Psikofarmakoloji Bulteni
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
11
Sayı
2
