Severe extrapyramidal symptoms due to sulpiride and fluoxetine combination in a case of OCD

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dc.authorscopusid7004232316
dc.authorscopusid6507784442
dc.authorscopusid7102067674
dc.contributor.authorKaya B.
dc.contributor.authorGüzelipek M.
dc.contributor.authorÖzcan M.E.
dc.date.accessioned2024-08-04T20:00:37Z
dc.date.available2024-08-04T20:00:37Z
dc.date.issued2001
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSulpiride is an antipsychotic agent which has an antidepressant effect in low doses. The combination of antipsychotics in lower dosages with antidepressants in obsessive-compulsive disorder (OCD) patients has also been reported to be useful. The case reported was a 53 years old female patient with OCD and major depression according to the DSM-IV diagnostic criteria. OCD diagnosis was present for six years and she had been depressied for the last six months. She was accepted as having resistant OCD according to the patient's history. After she was hospitalized, the treatment began with fluoksetin 20 mg/day. In the second week fluoksetin dosage was raised to 40 mg/day and 200 mg/day sulpiride was added. On the third day of combination treatment, severe extrapyramidal symptoms emerged and this prompted us to quit the use of sulpiride. Biperiden 3 mg/day was ordered in order to relieve those side effects. As these precautions were not efficacious, fluoksetin dosage was lowered to 20 mg/day, and then it was quitted. Diphenhidramine 100 mg/day, propranolol 40 mg/day and diazepam 10 mg/day were ordered. Except chewing movements extrapyramidal symptoms lasted for a week.en_US
dc.identifier.endpage123en_US
dc.identifier.issn1017-7833
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-52549092192en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage121en_US
dc.identifier.trdizinid14643en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/14643
dc.identifier.urihttps://hdl.handle.net/11616/90853
dc.identifier.volume11en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofKlinik Psikofarmakoloji Bultenien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDrug interactionen_US
dc.subjectExtrapyramidal symptomsen_US
dc.subjectFluoksetineen_US
dc.subjectObsessive-compulsive disordersen_US
dc.subjectSulpirideen_US
dc.titleSevere extrapyramidal symptoms due to sulpiride and fluoxetine combination in a case of OCDen_US
dc.typeArticleen_US

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