PREPARATION OF ALLANTOIN LOADED CHITOSAN NANOPARTICLES AND INFLUENCE OF MOLECULAR WEIGHT OF CHITOSAN ON DRUG RELEASE
Küçük Resim Yok
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, allantoin-loaded chitosan nanoparticles were prepared and the effect of molecular weights (low,medium, and high) of chitosan was investigated on the release of allantoin. The allantoin-loaded chitosannanoparticles were characterized by various methods. The morphology, size, zeta potential, and loadingefficiency were affected by the molecular weight of chitosan. The results displayed that the averagehydrodynamic diameter of chitosan nanoparticles was in the range of 427–768 nm and the zeta potential valuesfrom 5.97 to 5.12 mV was obtained. The allantoin release from chitosan nanoparticles reached the plateau levelin 96 hours. Cumulative allantoin release values of low, medium, and high molecular mass chitosannanoparticles were determined as 43%, 30%, and 27%, respectively. According to the results, the molecularweight of chitosan influenced on allantoin release.
Açıklama
Anahtar Kelimeler
Kaynak
İnönü üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
8
Sayı
3
