PREPARATION OF ALLANTOIN LOADED CHITOSAN NANOPARTICLES AND INFLUENCE OF MOLECULAR WEIGHT OF CHITOSAN ON DRUG RELEASE

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dc.contributor.authorUlu, Ahmet
dc.date.accessioned2024-08-04T19:51:47Z
dc.date.available2024-08-04T19:51:47Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, allantoin-loaded chitosan nanoparticles were prepared and the effect of molecular weights (low,medium, and high) of chitosan was investigated on the release of allantoin. The allantoin-loaded chitosannanoparticles were characterized by various methods. The morphology, size, zeta potential, and loadingefficiency were affected by the molecular weight of chitosan. The results displayed that the averagehydrodynamic diameter of chitosan nanoparticles was in the range of 427–768 nm and the zeta potential valuesfrom 5.97 to 5.12 mV was obtained. The allantoin release from chitosan nanoparticles reached the plateau levelin 96 hours. Cumulative allantoin release values of low, medium, and high molecular mass chitosannanoparticles were determined as 43%, 30%, and 27%, respectively. According to the results, the molecularweight of chitosan influenced on allantoin release.en_US
dc.identifier.doi10.33715/inonusaglik.759872
dc.identifier.endpage740en_US
dc.identifier.issn2147-7892
dc.identifier.issue3en_US
dc.identifier.startpage725en_US
dc.identifier.trdizinid420580en_US
dc.identifier.urihttps://doi.org/10.33715/inonusaglik.759872
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/420580
dc.identifier.urihttps://hdl.handle.net/11616/89264
dc.identifier.volume8en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofİnönü üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titlePREPARATION OF ALLANTOIN LOADED CHITOSAN NANOPARTICLES AND INFLUENCE OF MOLECULAR WEIGHT OF CHITOSAN ON DRUG RELEASEen_US
dc.typeArticleen_US

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