Investigating the protective effect of melatonin on liver injury relatedto myocardial ischemia reperfusion
Küçük Resim Yok
Dosyalar
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Medical science monitör
Erişim Hakkı
info:eu-repo/semantics/embargoedAccess
Özet
Background: An animal model of myocardial ischemia-reperfusion (MI/R) was used to test the hypothesis that free radicals released with MI/R have hazardous effects on liver through remote organ injury.
Material/Methods: Twenty-one rats were divided into three groups: sham-treated, MI/R, and MI/R+melatonin. To produce MI/R, a branch of the left coronary artery was occluded for 30 min followed by two hours of reperfusion. Melatonin or vehicle was given 10 min before ischemia. At the end of the study, liver tissue was obtained for biochemical determination. The false discovery rate (FDR) is explained and was used for multiple comparisons of the groups’ means.
Results: Compared with the sham group, MI/R significantly decreased glutathione (GSH) content and increased levels of nitric oxide (NO) and malondialdehyde (MDA). Melatonin administration significantly increased GSH levels and decreased the levels of NO and MDA compared with the MI/R group.
Conclusions: Melatonin could prevent liver damage due to its strong antioxidant and free radical scavenger effects. Therefore, melatonin may have beneficial effects on remote organ injury such as MI/R-induced liver disorders.
Açıklama
Anahtar Kelimeler
Animals, Rats, Wistar, Nitric Oxide - metabolism, Myocardial Reperfusion Injury - metabolism, Melatonin - therapeutic use, Malondialdehyde - metabolism, Male, Liver - metabolism, Glutathione - metabolism, Free Radical Scavengers - pharmacology, Antioxidants - pharmacology, Free Radical Scavengers - pharmacology
Kaynak
Medical science monitör
WoS Q Değeri
Scopus Q Değeri
Cilt
13
Sayı
11
Künye
Çolak, C. Parlakpınar, H. Özer, M. K. Şahna, E. Çiğremiş, Y. Acet, H. A. (2007). Investigating the protective effect of melatonin on liver injury relatedto myocardial ischemia reperfusion. Medical science monitör. 13(11), 251–254.
