Investigating the protective effect of melatonin on liver injury relatedto myocardial ischemia reperfusion

Basit Öğe Kaydı
dc.authorid9217en_US
dc.contributor.authorÇolak, Cemil
dc.contributor.authorParlakpınar, Hakan
dc.contributor.authorÖzer, Mehmet Kaya
dc.contributor.authorŞahna, Engin
dc.contributor.authorÇiğremiş, Yılmaz
dc.contributor.authorAcet, Hacı Ahmet
dc.date.accessioned2017-08-22T06:38:14Z
dc.date.available2017-08-22T06:38:14Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: An animal model of myocardial ischemia-reperfusion (MI/R) was used to test the hypothesis that free radicals released with MI/R have hazardous effects on liver through remote organ injury. Material/Methods: Twenty-one rats were divided into three groups: sham-treated, MI/R, and MI/R+melatonin. To produce MI/R, a branch of the left coronary artery was occluded for 30 min followed by two hours of reperfusion. Melatonin or vehicle was given 10 min before ischemia. At the end of the study, liver tissue was obtained for biochemical determination. The false discovery rate (FDR) is explained and was used for multiple comparisons of the groups’ means. Results: Compared with the sham group, MI/R significantly decreased glutathione (GSH) content and increased levels of nitric oxide (NO) and malondialdehyde (MDA). Melatonin administration significantly increased GSH levels and decreased the levels of NO and MDA compared with the MI/R group. Conclusions: Melatonin could prevent liver damage due to its strong antioxidant and free radical scavenger effects. Therefore, melatonin may have beneficial effects on remote organ injury such as MI/R-induced liver disorders.en_US
dc.identifier.citationÇolak, C. Parlakpınar, H. Özer, M. K. Şahna, E. Çiğremiş, Y. Acet, H. A. (2007). Investigating the protective effect of melatonin on liver injury relatedto myocardial ischemia reperfusion. Medical science monitör. 13(11), 251–254.en_US
dc.identifier.endpage254en_US
dc.identifier.issue11en_US
dc.identifier.startpage251en_US
dc.identifier.urihttps://hdl.handle.net/11616/7664
dc.identifier.volume13en_US
dc.language.isoenen_US
dc.publisherMedical science monitören_US
dc.relation.ispartofMedical science monitören_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAnimalsen_US
dc.subjectRatsen_US
dc.subjectWistaren_US
dc.subjectNitric Oxide - metabolismen_US
dc.subjectMyocardial Reperfusion Injury - metabolismen_US
dc.subjectMelatonin - therapeutic useen_US
dc.subjectMalondialdehyde - metabolismen_US
dc.subjectMaleen_US
dc.subjectLiver - metabolismen_US
dc.subjectGlutathione - metabolismen_US
dc.subjectFree Radical Scavengers - pharmacologyen_US
dc.subjectAntioxidants - pharmacologyen_US
dc.subjectFree Radical Scavengers - pharmacologyen_US
dc.titleInvestigating the protective effect of melatonin on liver injury relatedto myocardial ischemia reperfusionen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Makale Dosyası.docx
Boyut:
12.01 KB
Biçim:
Microsoft Word XML
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.71 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Tıp Fakültesi, Biyoistatistik ve Tıp Bilişimi Anabilim Dalı Koleksiyonu