Protective Role of Pistacia palaestina Boiss. Fruit and Leaf Extracts in Isoproterenol-Induced Cardiac Ischemia
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Society of Pharmaceutical Sciences of Ankara (FABAD)
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Myocardial infarction (MI) is one of the leading causes of death worldwide. This study aimed to investigate the protective effects of Pistacia palaestina Boiss (PP) leaf and fruit extracts, which are thought to have antioxidant and anti-inflammatory activity, in isoproterenol (ISO)-induced MI. 80 Sprague-Dawley rats were divided into ten groups. The control group was given 0.9% isotonic sodium chloride saline. PP leaf and fruit extracts at doses of 250 mg/kg and 500 mg/ kg were administered by oral gavage for 21 days. ISO 100 mg/kg subcutaneously was administered to the MI and MI-treatment groups on the 17th and 18th days of the experiment. Thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) levels, catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities were measured in heart tissue. In serum, troponin T, CK-MB; pro-inflammatory cytokine necrosis factor-alpha (TNF-?), interleukin-1? (IL-1?,) and IL-6; anti-inflammatory IL-10 levels were determined by the ELISA method. Heart tissue was examined by hematoxylin-eosin staining. While lipid peroxidation indicator TBARS activity increased in the MI group, antioxidant enzyme activities and GSH levels decreased. While troponin T, CK-MB, TNF-?, IL-1?, and IL-6 levels increased, anti-inflammatory IL-10 levels decreased. Low and high dose PP leaf and fruit extracts significantly decreased TBARS, troponin T, CK-MB, TNF-?, IL-1?, and IL-6 levels improved antioxidant enzyme activity, and GSH and IL-10 levels. PP ameliorated cardiac biomarkers and histopathological changes in ISO-induced MI by suppressing oxidative stress and inflammation. PP extracts may play an important cardioprotective role in the treatment of MI through their antioxidant and anti-inflammatory effects. © 2024 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.
Açıklama
Anahtar Kelimeler
anti-inflammatory activity, antioxidant, cardiac markers, isoproterenol, myocardial infarction, Pistacia palaestina boiss
Kaynak
Fabad Journal of Pharmaceutical Sciences
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
49
Sayı
1
