Protective Role of Pistacia palaestina Boiss. Fruit and Leaf Extracts in Isoproterenol-Induced Cardiac Ischemia

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dc.authorscopusid57053116200
dc.authorscopusid57222505412
dc.authorscopusid57211524435
dc.authorscopusid57192546285
dc.authorscopusid57478631600
dc.authorscopusid26024440900
dc.contributor.authorIçen M.S.
dc.contributor.authorYüce H.
dc.contributor.authorTürkmen N.B.
dc.contributor.authorTaşlidere A.
dc.contributor.authorÖzek D.A.
dc.contributor.authorÜnüvar S.
dc.date.accessioned2024-08-04T20:01:01Z
dc.date.available2024-08-04T20:01:01Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMyocardial infarction (MI) is one of the leading causes of death worldwide. This study aimed to investigate the protective effects of Pistacia palaestina Boiss (PP) leaf and fruit extracts, which are thought to have antioxidant and anti-inflammatory activity, in isoproterenol (ISO)-induced MI. 80 Sprague-Dawley rats were divided into ten groups. The control group was given 0.9% isotonic sodium chloride saline. PP leaf and fruit extracts at doses of 250 mg/kg and 500 mg/ kg were administered by oral gavage for 21 days. ISO 100 mg/kg subcutaneously was administered to the MI and MI-treatment groups on the 17th and 18th days of the experiment. Thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) levels, catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities were measured in heart tissue. In serum, troponin T, CK-MB; pro-inflammatory cytokine necrosis factor-alpha (TNF-?), interleukin-1? (IL-1?,) and IL-6; anti-inflammatory IL-10 levels were determined by the ELISA method. Heart tissue was examined by hematoxylin-eosin staining. While lipid peroxidation indicator TBARS activity increased in the MI group, antioxidant enzyme activities and GSH levels decreased. While troponin T, CK-MB, TNF-?, IL-1?, and IL-6 levels increased, anti-inflammatory IL-10 levels decreased. Low and high dose PP leaf and fruit extracts significantly decreased TBARS, troponin T, CK-MB, TNF-?, IL-1?, and IL-6 levels improved antioxidant enzyme activity, and GSH and IL-10 levels. PP ameliorated cardiac biomarkers and histopathological changes in ISO-induced MI by suppressing oxidative stress and inflammation. PP extracts may play an important cardioprotective role in the treatment of MI through their antioxidant and anti-inflammatory effects. © 2024 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.en_US
dc.description.sponsorshipTSA-2020-2146en_US
dc.description.sponsorshipThis study was supported by IUBAP (İnönü University Scientific Research Project Unit) numbered TSA-2020-2146. All authors would like to thank Prof. Dr. Turan Arabacı, who identified Pistacia palaestina Boiss. plant material.en_US
dc.identifier.doi10.55262/fabadeczacilik.1361591
dc.identifier.endpage196en_US
dc.identifier.issn1300-4182
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85189040725en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage181en_US
dc.identifier.trdizinid1229693en_US
dc.identifier.urihttps://doi.org/10.55262/fabadeczacilik.1361591
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1229693
dc.identifier.urihttps://hdl.handle.net/11616/91194
dc.identifier.volume49en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherSociety of Pharmaceutical Sciences of Ankara (FABAD)en_US
dc.relation.ispartofFabad Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanti-inflammatory activityen_US
dc.subjectantioxidanten_US
dc.subjectcardiac markersen_US
dc.subjectisoproterenolen_US
dc.subjectmyocardial infarctionen_US
dc.subjectPistacia palaestina boissen_US
dc.titleProtective Role of Pistacia palaestina Boiss. Fruit and Leaf Extracts in Isoproterenol-Induced Cardiac Ischemiaen_US
dc.typeArticleen_US

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