Evaluation of extensively drug-resistant gram-negative bacteremia among solid-organ transplant recipients: a multicenter study
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Abstract: Background/aim: The aim of this study is to evaluate the distribution, sources, clinical features, and mortality rates of bacteremia due to evaluation of extensively drug-resistant (XDR) gram negative among solid-organ transplant (SOT) recipients. Materials and methods: A retrospective study of SOT recipients with bacteremia due to XDR gram-negative pathogens in 11 centers between 2016 and 2018 was conducted. Patients’ records were evaluated. Results: Of 171 bacteremia that occurred in 164 SOT recipients, 93 (56.7%) were liver, 46 (28%) kidney, 14 (8.5%) heart, and 11 (6.7%) lung recipients. Bacteremia episodes were recorded in the first year in 63.7% of the patients (n = 109), early-onset bacteremia was recorded in 45% (n = 77) of the episodes. In multivariate analysis, catheter-associated bacteremia was an independent risk factor for 7-day mortality (p = 0.037), and early-onset bacteremia was found as an independent risk factor for 30-day mortality (p = 0.017). Conclusion: Difficult-to-treat infections due to XDR bacteria in SOT recipients shadow the success of transplantation. Central venous catheters seem to be the main risk factor. Judicious use of medical devices is of pivotal importance. Key words: Solid-organ transplant recipients, drug-resistant, bacteremia
Açıklama
Anahtar Kelimeler
Kaynak
Turkish Journal of Medical Sciences
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
51
Sayı
4
Künye
YALÇIN T. Y,AZAP Ö,KÖSE A,BAYİNDİR Y,SARICIOĞLU E. M,ÇINAR G,KIZMAZ Y. U,ORUÇ E,ALIŞKAN H. E,TEKÇE A. Y. T,KUTSOYLU O. Ö. E,EGELİ T,ARI A,ALBAYRAK Y,ÇABADAK H,DENİZ S,ÖNDER K. D,KIZILATEŞ F,ÖZGER H. S,TUNÇCAN Ö. G,HABERAL M (2021). Evaluation of extensively drug-resistant gram-negative bacteremia among solid-organ
transplant recipients: a multicenter study. Turkish Journal of Medical Sciences, 51(4), 1960 - 1968. Doi: 10.3906/sag-2101-161
