Evaluation of extensively drug-resistant gram-negative bacteremia among solid-organ transplant recipients: a multicenter study

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dc.contributor.authorYANIK YALÇIN, Tuğba
dc.contributor.authorAZAP, Özlem
dc.contributor.authorKöse, Adem
dc.contributor.authorBayındır, Yaşar
dc.contributor.authorSARICAOĞLU, Elif Mükime
dc.contributor.authorÇINAR, Güle
dc.contributor.authorUYGUN KIZMAZ, Yeşim
dc.contributor.authorKURŞUN, Ebru
dc.contributor.authorALIŞKAN, Hikmet
dc.contributor.authorTEZER TEKÇE, Yasemin
dc.contributor.authorEREN, Oya
dc.contributor.authorEGELİ, Tufan
dc.contributor.authorARI, Alpay
dc.contributor.authorALBAYRAK, Yurdagül
dc.contributor.authorÇABADAK, Hatice
dc.contributor.authorDENİZ, Seçil
dc.contributor.authorDEMİR ÖNDER, Kübra
dc.contributor.authorKIZILATEŞ, Filiz
dc.contributor.authorÖZGER, Selçuk
dc.contributor.authorGÜZEL TUNÇCAN, Özlem
dc.contributor.authorHABERAL, Mehmet
dc.date.accessioned2022-02-09T09:10:35Z
dc.date.available2022-02-09T09:10:35Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAbstract: Background/aim: The aim of this study is to evaluate the distribution, sources, clinical features, and mortality rates of bacteremia due to evaluation of extensively drug-resistant (XDR) gram negative among solid-organ transplant (SOT) recipients. Materials and methods: A retrospective study of SOT recipients with bacteremia due to XDR gram-negative pathogens in 11 centers between 2016 and 2018 was conducted. Patients’ records were evaluated. Results: Of 171 bacteremia that occurred in 164 SOT recipients, 93 (56.7%) were liver, 46 (28%) kidney, 14 (8.5%) heart, and 11 (6.7%) lung recipients. Bacteremia episodes were recorded in the first year in 63.7% of the patients (n = 109), early-onset bacteremia was recorded in 45% (n = 77) of the episodes. In multivariate analysis, catheter-associated bacteremia was an independent risk factor for 7-day mortality (p = 0.037), and early-onset bacteremia was found as an independent risk factor for 30-day mortality (p = 0.017). Conclusion: Difficult-to-treat infections due to XDR bacteria in SOT recipients shadow the success of transplantation. Central venous catheters seem to be the main risk factor. Judicious use of medical devices is of pivotal importance. Key words: Solid-organ transplant recipients, drug-resistant, bacteremiaen_US
dc.identifier.citationYALÇIN T. Y,AZAP Ö,KÖSE A,BAYİNDİR Y,SARICIOĞLU E. M,ÇINAR G,KIZMAZ Y. U,ORUÇ E,ALIŞKAN H. E,TEKÇE A. Y. T,KUTSOYLU O. Ö. E,EGELİ T,ARI A,ALBAYRAK Y,ÇABADAK H,DENİZ S,ÖNDER K. D,KIZILATEŞ F,ÖZGER H. S,TUNÇCAN Ö. G,HABERAL M (2021). Evaluation of extensively drug-resistant gram-negative bacteremia among solid-organ transplant recipients: a multicenter study. Turkish Journal of Medical Sciences, 51(4), 1960 - 1968. Doi: 10.3906/sag-2101-161en_US
dc.identifier.doi10.3906/sag-2101-161en_US
dc.identifier.endpage1968en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4en_US
dc.identifier.pmid33865241en_US
dc.identifier.scopus2-s2.0-85114851700en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1960en_US
dc.identifier.trdizinid480657en_US
dc.identifier.urihttps://doi.org/10.3906/sag-2101-161
dc.identifier.urihttps://hdl.handle.net/11616/46988
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/480657
dc.identifier.volume51en_US
dc.identifier.wosWOS:000691544700047en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEvaluation of extensively drug-resistant gram-negative bacteremia among solid-organ transplant recipients: a multicenter studyen_US
dc.typeArticleen_US

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